Overview

By partnering with West Nile virus surveillance labs across the country, the WestNile 4K Project is planning to sequence more than 4,000 virus genomes to reconstruct a high definition picture of West Nile virus spread and evolution during the last 20 years in the United States. The data that they generate will be immediately released and, along with other entomological data, will be used to uncover local transmission dynamics. As little progress has been made in effectively controlling West Nile virus outbreaks since its emergence, their goal is to use fine-scale transmission networks revealed through virus genomics to better design targeted control measures

790
Genomes
1
Countries
32
States
42
Institutions
83
Collaborators

Leadership

Nate Grubaugh

Assistant Professor, Yale School of Public Health

Nathan D. Grubaugh, M.S., Ph.D. is an Assistant Professor at the Yale School of Public Health in the department of Epidemiology of Microbial Diseases. He spent ~7 years working in the biotech sector before earning a M.S. in biotechnology from Johns Hopkins University in 2011 and a Ph.D. in microbiology from Colorado State University in 2016. Nate did his postdoctoral training in pathogen genomics under the guidance of Kristian Andersen at Scripps Research before joining the faculty at Yale in 2018.

Nate is trained as an arbovirologist, and has used his diverse background in private, government, and academic research to develop molecular strategies to detect, track, and understand mosquito-borne virus outbreaks. Having studied the ecology and evolution of West Nile virus during his Ph.D., a primary objective in his lab is to expand this work into using genomic epidemiology to inform targeted control measures.

Nate Grubaugh

Assistant Professor

Yale School of Public Health
Department of Epidemiology of Microbial Diseases

Ryan Smith

Ryan Smith

Assistant Professor, Iowa State University

Ryan C. Smith, Ph.D. is an Assistant Professor in the Department of Entomology at Iowa State University. He earned his degree in molecular biology at the University of California Riverside working on mosquito genetics, then did his post-doctoral training at the Johns Hopkins Bloomberg School of Public Health focusing on mosquito host-pathogen interactions. Ryan joined the faculty at Iowa State in 2015 establishing a research program with both lab- and field-based components to better understand mosquito-borne disease transmission.

These experiences have led Ryan to explore how mosquitoes transmit diseases like malaria and Zika virus. Ryan also oversees mosquito and West Nile virus surveillance in the state of Iowa, working closely with local and state public health partners to monitor potential disease outbreaks and to investigate the epidemiological factors that contribute to West Nile virus transmission. Ryan is a member of the Midwest Regional Center for Vector-borne disease, leading efforts to enhance the capacity to anticipate, prevent, and control vector-borne diseases.

Ryan Smith

Assistant Professor

Iowa State University
Department of Entomology

kristian

Kristian Andersen

Associate Professor, Scripps Research

Kristian Andersen, PhD is an associate professor in the Department of Immunology and Microbiology at Scripps Research, with joint appointments in the Department of Integrative Structural and Computational Biology, and at the Scripps Research Translational Institute. Over the past decade, his research has focused on the complex relationship between host and pathogen. Using a combination of next-generation sequencing, field work, experimentation, and computational biology he has spearheaded large international collaborations investigating the spread and evolution of deadly pathogens, including Zika virus, Ebola virus, West Nile virus, and Lassa virus. His work is highly cross-disciplinary and exceptionally collaborative.

Kristian earned his doctoral degree from the University of Cambridge in immunology and performed postdoctoral work in Pardis Sabeti's group at Harvard University and the Broad Institute. He has received several awards, including the Max Perutz Prize in 2008, a Carlsberg Foundation Fellowship in 2009, and was chosen as a PEW Biomedical Scholar in 2016.

Kristian Andersen

Associate Professor

Scripps Research
Department of Immunology and Microbiology

Team

Karthik Gangavarapu

Graduate Student
Scripps Research

Nate Matteson

Graduate Student
Scripps Research

Refugio Robles

Lab Manager
Scripps Research

chantal

Chantal Vogels

Postdoc
Yale School of Public Health

anderson_b

Anderson Brito

Postdoc
Yale School of Public Health

mary_p

Mary Petrone

Graduate Student
Yale School of Public Health

Partners

City of Sioux Falls
Denise Patton

Champaign-Urbana Public Health District
Jeff Blackford

Colorado State University
Greg Ebel
Reyes Murrieta
Joseph Fauver

Connecticut Agricultural Experiment Station
Phil Armstrong
John Shepard
Ted Andreadis
John Anderson

Eastern Washington University
Krisztian Magori

Florida Department of Health
Andrea Morrison

Grand Forks Health Department
Todd Hanson

Idaho Department of Health and Welfare
Vonnita Barton

Illinois Natural History Survey
Chris Stone

Indiana Department of Health
Bryan Price

Iowa Department of Public Health
Ann Garvey
Julie Coughlin

Kansas Biological Survey / The University of Kansas
Christopher Rogers

Louisiana Animal Disease Diagnostic Laboratory / Louisiana State University
Udeni Balasuriya
Rebecca Christofferson
Tarra Harden
Zelalem Mekuria
Laura Peak
Alma Roy
Keith Strother

Kansas Department of Health and Environment
Ingrid Garrison
Amie Cook

Maine Medical Center Research Institute
Chuck Lubelczyk

Metropolitan Mosquito Control District
Kirk Johnson

Michigan State University
Michael Kaufman
Ned Walker
Trisha Dubie

Minnesota Department of Health
Dave Nietzel

Mississippi Department of Health
Wendy Varnado

Nebraska Department of Health
Jeff Hamik

Nebraska Public Health Laboratory
Pete Iwen
Vicki Herrera

New Hampshire Division of Public Health Services
Denise Bolton
Abigail Mathewson
Carolyn Fredette
Rebecca Lovell
Amy Kutschke

North Shore Mosquito Abatement District
Mark Clifton

Ohio Department of Health
Leeanne Garrett
Kevin Sohner

Oregon Veterinary Diagnostic Laboratory / Oregon State University
Donna Mulrooney
Manoj Pastey
Justin Sanders
Andree Hunkapiller
Noah Lawler
Sarah Greene

Pennsylvania Department of Agriculture
Michael Hutchinson

Pennsylvania Department of Environmental Protection
Keith Price

San Diego Vector Control
Nikos Gurfield
Saran Grewal

South Dakota Department of Public Health
Chris Carlson

Southern Nazarene University
Caio França

St. Louis County Vector Control
Tony Patullo

Texas Department of State Health Services
Bethany Bolling

University of California, Davis
Chris Barker
Sarah Wheeler
Ying Fang
Lark Coffey
William Reisen

University of Georgia
Daniel Mead
Isabel Ott

University of Iowa / State Hygeinic Lab
Lucy Desjardin
Jeff Benfer

University of South Alabama
Jonathan Rayner
Ryan Wood
John McCreadie

Vermont Department of Health Laboratory
Christine Matusevich
Patti Casey
Eliza Doncaster

Washington Department of Health
Amy Salamone
Elizabeth Dykstra
Erin Knutson
Anne Duffy

Washington State University
Dan Bradway
Becca Wolking
Marla Francis